HIGHLY EFFICIENT AND EXPEDITED HEPATIC DIFFERENTIATION FROM HUMAN PLURIPOTENT STEM CELLS BY PURE SMALL-MOLECULE COCKTAILS

Highly efficient and expedited hepatic differentiation from human pluripotent stem cells by pure small-molecule cocktails

Abstract Background The advent of human-induced pluripotent stem cells holds great promise for producing ample individualized hepatocytes.Although previous efforts have succeeded in generating hepatocytes from human pluripotent stem cells in vitro by viral-based expression of transcription factors wall-e bearbrick and/or addition of growth factors

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The pathogenesis of bullous skin diseases

Bullous skin diseases are a group of dermatoses characterized by blisters and bullae in the skin and mucous membranes.The etiology and pathogenesis of bullous pabst blue ribbon chandelier skin diseases are not completely clear.The most common are pemphigus and bullous pemphigoid (BP).Autoantibodies play critical roles in their pathogenesis.Abnormal

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New Method for High Water Pressure Tunnel Design Based on Machine Learning for Smart Grid Energy Management and Groundwater Environmental Balance

In recent years, underwater shield tunnels are being developed according to large-scale sections.The problems of large buried depth and high water pressure have posed major challenges to the safety of segmented structures.The load-bearing capacity and damage of segmented structures under high water pressure features have always attracted attention.

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